2025 March Madness Final Four Odds: Duke Leads All 68 Teams as Heavy Favorite
The 2025 NCAA Tournament bracket is set with odds available for teams to reach the Final Four. All four #1 seeds are favorites to win their respective regions.
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East Region Odds
- Duke (#1): -115
- Alabama (#2): +475
- Wisconsin (#3): +900
- Arizona (#4): +950
Duke, with Cooper Flagg returning from injury, leads all teams with the best Final Four odds. They top KenPom ratings at +38.16, significantly ahead of second-ranked Florida (+36.16).
Midwest Region Odds
- Houston (#1): +155
- Tennessee (#2): +340
- Kentucky (#3): +850
- Gonzaga (#8): +850
- Illinois (#6): +850
Houston dominates after a 19-1 Big 12 season. Gonzaga, despite being an 8-seed, shares third-best odds and maintains a nine-game Sweet 16 streak.
South Region Odds
- Auburn (#1): +110
- Michigan State (#2): +470
- Iowa State (#3): +600
- Texas A&M (#4): +1200
Auburn leads despite recent struggles. Notable: #11 North Carolina (+4500) ranks ahead of several higher seeds, including #10 New Mexico (+6500).
West Region Odds
- Florida (#1): -110
- Texas Tech (#3): +470
- St John's (#2): +600
- Colorado State (#12): +6500
- Memphis (#5): +9000
Florida, fresh off an SEC Tournament victory, stands as the region's clear favorite. Uniquely, #12 Colorado State is favored over #5 Memphis in their first-round matchup, reflected in their respective Final Four odds.
This comprehensive outlook considers recent performance, injuries, and historical trends across all regions heading into March Madness 2025.