White Sox vs Guardians April 21: Betting Guide and Series Finale Preview

White Sox vs Guardians April 21: Betting Guide and Series Finale Preview

By Michael Davidson

February 12, 2025 at 04:45 AM

After a weather-delayed series, the Cleveland Guardians face the Chicago White Sox in their series finale on April 21 at 1:10 p.m. The Guardians lead the series 2-0 after winning both games of Wednesday's doubleheader.

Game Details:

  • White Sox (-140) vs Guardians (+117)
  • Run line: Guardians +1.5 (-140)
  • Over/Under: 8 runs

Pitching Matchup:

  • White Sox: Dylan Cease (2-0, 1.69 ERA, 16 K, 0.94 WHIP)
  • Guardians: Zach Plesac (0-1, 1.64 ERA)

Key Performers:

  • White Sox: Andrew Vaughn (.310/.375/.552, 2 HR, 6 RBI)
  • Guardians: Jose Ramirez (.429/.479/.881, 4 HR, 20 RBI)

Series Recap:

  • Game 1: Guardians won 11-1 (Ramirez grand slam)
  • Game 2: Guardians won 2-1 (McKenzie: 4.1 IP, 1 ER)

Notable Matchups:

  • vs Plesac: Luis Robert (5-for-10), Jose Abreu and Tim Anderson (3 combined HR in 35 AB)

Despite Cleveland's series lead, Chicago enters as favorites behind Cease's strong start to the season. The Guardians look to complete the sweep behind Plesac's solid pitching and Ramirez's hot bat.

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