Sweet 16 Odds 2025: Complete Betting Guide for All 68 NCAA Tournament Teams
The 2025 NCAA Tournament field is set with 68 teams vying for glory. Here's a comprehensive breakdown of Sweet 16 odds and best betting picks.
Top Favorites (Odds via BetMGM)
Duke (-650) and Florida (-650) lead the pack as co-favorites to reach the Sweet 16. Duke rides freshman sensation Cooper Flagg's impressive stats (19.1 PPG, 8.3 RPG, 3.9 APG), while Florida boasts the nation's most efficient offense behind Walter Clayton Jr. and Will Richard.
Gators celebrate on basketball court
Houston (-300) and Auburn (-400) round out the #1 seeds with strong chances to advance. Houston brings their trademark elite defense, while Auburn relies on All-American candidate Johni Broome.
Value Picks
- Tennessee (-275): Third-best defensive efficiency nationally
- St. John's (-150): Country's top defensive team under Rick Pitino
- Colorado State (+350): Hot streak with dominant conference run
- Gonzaga (+250): Elite offense with NBA prospect Seamus Boone
Longshot Opportunities
Grand Canyon (+1400) emerges as this year's potential bracket buster under coach Bryce Drew. Their defensive prowess and upset experience make them dangerous.
CBS Sports Game Highlights
Yale (+900) deserves consideration after last year's Auburn upset. Led by Bez Mbeng, their disciplined style could cause problems for higher seeds.
Teams to Avoid
- Kentucky (+110): Too inconsistent despite talent
- Kansas (+190): Defensive concerns and tough draw
- Wisconsin (-115): Overvalued #3 seed lacking elite metrics
- UConn (+600): Defensive efficiency outside top 90
Basketball players jumping for ball
Strategy Tip: Mix safe favorites with calculated value plays and selective longshots for optimal Sweet 16 betting returns.
Remember: Check current odds before placing bets, as lines may shift leading up to tipoff. Always bet responsibly and within your means.
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