The San Francisco 49ers (6-6) face the Cincinnati Bengals (7-5) at Paul Brown Stadium on CBS at 4:25 p.m. The Bengals trail the Ravens by one game in the AFC North, while the 49ers sit third in the NFC West.

Game Details:

• Spread: 49ers -1 (-110)
• Moneyline: 49ers -120, Bengals +100
• Over/Under: 40 points (-110)
• Combined scoring average: 52.9 points per game
• Combined points allowed: 45.5 points per game
• ATS records: 49ers 5-7, Bengals 6-6

Keys for Cincinnati:

• Defense must improve after struggling against Chargers
• Joe Burrow needs to return to multi-touchdown form
• Critical game for playoff hopes with Ravens matchup looming

Keys for San Francisco:

• Continue strong running game (48.3% run rate, 3rd in NFL)
• Leverage big-play passing (8 yards per attempt)
• Defense must maintain strong third-down defense (ranks 9th)
• Control time of possession

Both teams are coming off losses - Bengals fell 41-22 to Chargers, while 49ers lost 30-23 to Seahawks. The 49ers' defense ranks 6th in opponent yards per game, making this a crucial matchup for both teams' playoff aspirations.

The game features two contrasting styles: San Francisco's run-heavy approach versus Cincinnati's passing attack. Success on third downs and turnover margin likely determine the winner in what projects as a close contest.

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