Cleveland Guardians vs. San Diego Padres: August 24 MLB Betting Guide and Odds

Cleveland Guardians vs. San Diego Padres: August 24 MLB Betting Guide and Odds

By Michael Davidson

March 24, 2025 at 12:43 PM

The Cleveland Guardians (65-56) face the San Diego Padres (68-57) in the finale of their two-game interleague series at Petco Park, with first pitch at 4:10 pm ET.

The Guardians won the opener 3-1 behind home runs from Oscar Gonzalez and Andres Gimenez, plus an RBI single from Jose Ramirez. Aaron Civale and the bullpen combined to limit the Padres to just one run.

Betting Odds:

  • Padres: -158 (favorites)
  • Guardians: +134
  • Run line: Guardians +1.5 (-160)
  • Over/Under: 7.5 runs

Pitching Matchup:

  • Guardians: Cal Quantrill (9-5, 3.77 ERA)
  • Padres: Blake Snell (5-6, 3.76 ERA)

Key Points:

  • Guardians look to extend AL Central lead after division rivals lost Tuesday
  • Jose Ramirez hitting .333 with a HR against Snell lifetime
  • Padres hold slim 1-game lead for final Wild Card spot
  • Juan Soto (back) questionable after missing Tuesday's game
  • Padres averaging 3.93 runs per game at home (15th in MLB)

The Guardians have a strong opportunity to complete the sweep with Quantrill on the mound, especially if Soto remains out. The Padres' mediocre home offense could struggle against Cleveland's pitching.

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