MLB Top Three-Team Parlay Picks for September 22 - Yankees, Brewers, Guardians Featured

MLB Top Three-Team Parlay Picks for September 22 - Yankees, Brewers, Guardians Featured

By Michael Davidson

March 17, 2025 at 05:41 PM

Looking to build a profitable MLB parlay for September 22nd? Here's a three-team combination with strong value, focusing on critical late-season matchups:

Milwaukee Brewers (-150) vs Cincinnati Reds

  • Brandon Woodruff (11-4, 3.26 ERA) starting for Brewers
  • Brewers fighting for Wild Card spot, 2.5 games back
  • Facing struggling Hunter Greene (4-12) and weak Reds team

New York Yankees (-170) vs Boston Red Sox

  • Yankees coming off 14-2 win over Pirates
  • Aaron Judge red-hot with 60 home runs
  • Yankees lead Red Sox by 97 HRs this season
  • Strong offensive advantage in rivalry matchup

Cleveland Guardians (-135) vs Chicago White Sox

  • Shane Bieber (11-8) starting, top-15 in ERA/WHIP/Ks
  • Guardians lead season series 11-7
  • Six-game lead in AL Central
  • White Sox have negative run differential

Each pick features strong pitching matchups, playoff implications, and favorable offensive situations. This parlay offers solid value while targeting teams with clear competitive advantages in crucial September contests.

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