Here's the concise, valuable rewrite focusing on MLB Opening Day betting odds and predictions for April 7, 2022:

Opening Day MLB betting guide featuring seven exciting matchups across the league:

Brewers (-1.5) at Cubs | Total: 10 | 2:21 PM ET

• Brewers dominated Cubs 15-4 last season
• Pitching: Corbin Burnes (11-5, 2.43 ERA) vs Kyle Hendricks (14-7, 4.77 ERA)
• Prediction: Brewers -1.5 and Under 10

Guardians (-1.5) at Royals | Total: 8 | 4:11 PM ET

• Key matchup: Shane Bieber vs Zack Greinke
• Watch: José Ramírez (.266, 36 HR, 103 RBI last season)
• Prediction: Royals +1.5 and Under 8

Pirates at Cardinals (-1.5) | Total: 8 | 4:16 PM ET

• Cardinals' strong offense (4.34 runs/game) vs Pirates' weak offense (3.76)
• Veteran Adam Wainwright starting for Cardinals
• Prediction: Cardinals -1.5 and Under 8

Mets (-1.5) at Nationals | Total: 9 | 7:06 PM ET

• Tylor Megill (4-6, 4.52 ERA) vs Patrick Corbin (9-16, 5.82 ERA)
• High-scoring potential with strong lineups
• Prediction: Mets -1.5 and Over 9

Reds at Braves (-1.5) | Total: 8 | 8:09 PM ET

• World Series champs debut with Max Fried (14-7, 3.04 ERA)
• Reds significantly weakened after offseason departures
• Prediction: Braves -1.5 and Under 8

Astros at Angels (-1.5) | Total: 8.5 | 9:39 PM ET

• MVP Shohei Ohtani (9-2, 3.18 ERA) starts for Angels
• Astros seek 10th straight Opening Day win
• Prediction: Astros +1.5 and Over 8.5

Padres (-1.5) at Diamondbacks | Total: 9 | 9:41 PM ET

• Yu Darvish vs Madison Bumgarner
• Padres went 11-8 vs Diamondbacks last season
• Prediction: Padres -1.5 and Under 9

Note: All times Eastern. Odds subject to change.

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