
McNeese vs Purdue Betting Preview: Boilermakers Open as 7.5-Point Favorites in Second Round
The #12 McNeese Cowboys (28-6) will face the #4 Purdue Boilermakers (23-11) in the second round of the 2025 NCAA Tournament after both teams secured impressive first-round victories.

Basketball player celebrating victory pose
Opening Odds:
- Spread: Purdue -7.5
- Moneyline: Purdue -325, McNeese +260
- Total: 139.5 (-110 both ways)
First Round Performances:
- McNeese defeated #5 Clemson 69-67 as 7.5-point underdogs
- Purdue handled #13 High Point convincingly with a strong first-half performance
Key McNeese Stats vs Clemson:
- Led by 18 at halftime
- Christian Shumate: 13 points, 11 rebounds
- Brandon Murray: 21 points off the bench
- Outrebounded Clemson by 6
- Recorded 6 blocks to Clemson's 0

March Madness Selection Show
Key Purdue Highlights:
- Trey Kauffman-Renn: 21 points (10-16 FG), 8 rebounds
- 14-1 record against teams outside KenPom top 50
- Current Final Four odds: +1000
Head-to-Head Context:
- Only common opponent: Alabama
- McNeese lost 72-64 (away)
- Purdue won 87-78 (home)
This second-round matchup will take place in Providence, RI, with Purdue favored to advance to their second consecutive Sweet 16, while McNeese seeks their first-ever Sweet 16 appearance.
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