March Madness 2025: Best Underdog Upset Picks & Bracket Predictions
March Madness has arrived, bringing the excitement of potential bracket-busting upsets. Here are the most likely tournament upsets and best underdogs to consider betting in 2025.
Two basketball players face off court
Most Likely First-Round Upsets:
#12 Colorado State over #5 Memphis
- Rams are betting favorites
- Top-3 in Mountain West scoring offense and defense
- Strong matchup against Tigers' style of play
#10 Arkansas over #7 Kansas
- Razorbacks boast 6th-best SEC scoring defense
- Well-equipped to challenge Jayhawks
#12 UC San Diego over #5 Michigan
- Impressive 30-4 record
- #1 in Big West scoring defense
- #3 in conference scoring
High-Seed Upset Potential:
13-Seed: Akron (+750) over Arizona
- MAC's top scoring offense (84.6 PPG)
- Arizona's defense ranks 13th in conference
- 11.6% implied probability
14-Seed: Troy (+500) over Kentucky
- Top-3 Sun Belt scoring defense
- Kentucky allows 77.9 PPG (SEC second-worst)
- 16.67% implied probability
15-Seed: Bryant (+1250) over MSU
- American East scoring leaders (86.4 PPG)
- 7.41% implied probability
Best Value Betting Underdogs:
New Mexico (+150)
- Mountain West's top scoring offense (81.2 PPG)
- 34.7% from three-point range
- Fourth-fastest tempo (KenPom)
- Marquette enters having lost 3 of 4
Grand Canyon (+450)
- WAC scoring leaders (79.9 PPG)
- Matches up well with Maryland's pace
- 18.18% implied win probability
BACK IN FRONT! @Donovandent1 📺 @CBSSportsNet #GoLobos | #MWMadness pic.twitter.com/wC0PMBaFOc
Remember to check public betting splits and current odds before placing any bets. Past performance doesn't guarantee future results.
Must be 21+. GAMBLING PROBLEM? Call 1-800-GAMBLER