The Cleveland Browns (3-2) face the undefeated Arizona Cardinals (5-0) in a crucial Week 6 matchup. The Browns are looking to bounce back after a wild 47-42 loss to the Chargers, while the Cardinals aim to maintain their perfect record following a 17-10 win over the 49ers.

Kyler Murray continues his MVP-caliber season, leading Arizona's top-5 offense with over 320 passing yards per game plus dangerous rushing ability. The Cardinals' defense has been quietly effective, holding four of five opponents to 20 points or less, though they'll miss Chandler Jones this week.

Cleveland's powerful rushing attack remains their offensive foundation, with Nick Chubb and Kareem Hunt combining for over 220 yards and three touchdowns last week. Baker Mayfield showed improvement with a 300+ yard passing performance, but the Browns' defense struggled significantly, allowing 47 points including four fourth-quarter touchdowns.

Key Factors:

• Cardinals' offense averaging 30+ points in four straight games before last week
• Browns' defense showing vulnerability, especially in the secondary
• Early East Coast start time potentially favoring Cleveland
• Arizona missing key defender Chandler Jones
• Browns' run game remains elite with Chubb/Hunt duo

The Browns have home-field advantage and traditionally teams traveling east for early games struggle. However, they'll need a much-improved defensive effort to contain Murray and hand Arizona their first loss.

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