
Ohio State vs Indiana Betting Odds & Prediction: Undefeated Hoosiers Face Biggest Test in Week 13
#2 Ohio State faces undefeated #5 Indiana as 11.5-point home favorites in a crucial Week 13 Big Ten matchup. The Buckeyes must win to secure their spot in the Big Ten Championship Game.

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The Hoosiers (10-0, 7-0 Big Ten) have dominated with the nation's best point differential (301) and nine wins by 14+ points. They lead in points per play and red zone efficiency, ranking third in scoring. Their defense ranks top-10 in scoring and yards allowed.
However, Indiana's strength of schedule ranks 100th nationally, with opponents averaging just a 49.4% winning percentage. Their only close game came against Michigan in Week 11, where they struggled offensively in the second half.
Ohio State (9-1, 6-1 Big Ten) has faced tougher competition, with their lone loss coming by one point to #1 Oregon. Key achievements include:
- Leading the nation in scoring defense
- Ranking second in total yards allowed
- Holding last four opponents under 18 points and 275 yards
- Top-10 in most offensive metrics
The betting line opened at Buckeyes -12.5 but has shifted to -11.5 with heavy Indiana action. The Hoosiers are receiving 67% of spread tickets and 64% of the handle.
Early Prediction: Indiana's strong defense (4th in EPA per play) and Ohio State's 5-5 ATS record suggest the Hoosiers can keep this competitive. Their Week 12 bye allowed key players to heal, and their defense limits explosive plays effectively.
Pick: Indiana +11.5 (-110)
The spread will likely continue moving in Indiana's favor due to public betting trends, so securing the current line is recommended before it crosses key numbers.
BSB Advanced Stat Preview: Indiana at Ohio State pic.twitter.com/fq0V3JHge4
— taylor from bite-sized bison (@ByTaylorL) November 18, 2024
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