With six teams on bye in Week 12, twelve total games are scheduled for Sunday and Monday. Two matchups feature double-digit spreads, with favorites of ten points or higher going 5-0 against the spread this season. The Commanders (-10.5) and Chiefs (-10.5) could present valuable opportunities.

Packers -3 vs 49ers

The 49ers (5-5) are struggling, sitting fourth in the NFC West. Under Kyle Shanahan, San Francisco is 1-3 against Green Bay in regular season games. With Purdy's shoulder issues and Bosa questionable, the Packers' fourth-ranked takeaway defense and improving offense under Jordan Love make them a strong pick to cover at home in cold conditions.

Cardinals +1 vs Seahawks

Coming off a bye week, the Cardinals face a Seahawks team that's 1-5 ATS at home under Geno Smith this season. Kyler Murray's efficiency and James Conner's running ability should exploit Seattle's 27th-ranked rushing defense. Arizona's defense has been solid, allowing just 15 points in their last two games combined.

The Cardinals' fifth-best rushing attack matches up well against Seattle's vulnerable run defense. Arizona's momentum and extra preparation time make them a strong road underdog pick.

Eagles -3 vs Rams

Philadelphia enters this Sunday Night Football matchup with a 4-1 ATS road record and three straight wins against the Rams. Their potent rushing attack led by Barkley and Hurts should dominate, while AJ Brown provides a serious passing threat against LA's secondary.

The Eagles' league-leading pass defense and strong front seven should contain a Rams offense dealing with offensive line injuries. Philadelphia's balanced attack and defensive prowess make them a solid favorite to cover on the road.

All odds via ESPN BET as of November 22.

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