NFL Thanksgiving Day 2021: Expert Moneyline Predictions and Analysis

NFL Thanksgiving Day 2021: Expert Moneyline Predictions and Analysis

By Michael Davidson

March 19, 2025 at 07:29 PM

Looking for expert NFL Thanksgiving Day betting picks? Here's a comprehensive analysis of all three games with moneyline predictions:

Bears @ Lions (12:30 PM ET, FOX)

  • Lions look to secure first win after close games vs Steelers (tie) and Browns
  • Bears dealing with coaching drama and key injuries (No Fields, Mack out)
  • Lions ML (+135) projected to finally break through

Raiders @ Cowboys (4:30 PM ET, CBS)

  • Cowboys aim to bounce back after Chiefs loss
  • Raiders on 2-game skid with blowout losses
  • Missing Ruggs hurts Raiders' offense
  • Cowboys ML (-335) favored to win at home

Bills @ Saints (8:20 PM ET, NBC)

  • Bills' run game struggles a concern
  • Saints limited offensively beyond Kamara
  • Bills ML (-278) should prevail despite inconsistency

Parlay Option: Bills + Cowboys + Lions ML parlay offers +315 odds

Game Day Takeaway: While individual moneylines offer safer plays, the three-team parlay provides an enticing risk/reward opportunity for bettors looking for bigger potential payout.

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*Odds and lines subject to change. Please gamble responsibly.

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